2 Nov. 1788–13 Apr. 1853
In 1815 Iredell was appointed a brigadier general of North Carolina militia. He was elected from Edenton as a member of the North Carolina General Assembly in 1813 and served again in 1816–28; from 1817 to 1827 he was speaker of the house. Iredell was elected governor of North Carolina in 1827 and served for a few months before his election to the U.S. Senate to complete the unexpired term of Nathaniel Macon, upon the latter's resignation.
Perhaps much of Iredell's claim to fame was as the son of his illustrious father, who was active in colonial and early state government prior to his appointment to the United States Supreme Court by President George Washington. His uncle and mentor, Samuel Johnston, was equally active in the early history of the colony and state, particularly in the organization of the Revolutionary government and the Continental Congress and later as governor and member of the U.S. Senate. Johnston sponsored his nephew's education at Princeton. The younger Iredell's term as governor was too brief for any outstanding accomplishments. In addressing the General Assembly after his election, he proposed continuation of the program of former governors in emphasizing internal improvements and the development of educational facilities. Joseph Caldwell's Numbers of Carlton envisioned a program of railroad expansion to open the western section of the state, providing transportation for the products of that region to a North Carolina port and foreign markets. Iredell suggested the construction of a trial road from Campbellton to Fayetteville.
Iredell did not seek reelection to the U.S. Senate after completing Macon's term. Instead, he returned to North Carolina and moved to Raleigh to practice law. In 1836–37 he was a commissioner to revise the state laws, and from 1840 to 1852 he was a reporter for the North Carolina Supreme Court. He prepared a Digest of All the Reported Cases Determined in the Courts of North Carolina, from the Year 1778 to the Year 1845, published in three volumes in Raleigh between 1839 and 1846.
Iredell's wife was the daughter of Samuel Treadwell, collector of the Port of Edenton. They were the parents of seven children: Frances, Penelope, Annie, Jane, James, Helen, and Samuel. Iredell died in Edenton and was buried in the Johnston family cemetery at Hayes Plantation in Edenton.