| Ephraim Branch | rises in N Haywood County and flows SW into Groundhog Creek. |
| Ephraim Hensley Mountain | N Madison County between Rick Branch and Big Creek. |
| Ephraim Place | mountain on the Mitchell County, N.C.-Unicoi County, Tenn., line. |
| Epping Forest | an eighteenth-century community and census district in SW Vance County. The community was located near the present town of Kittrell. In 1790 the district had 65 heads of families. |
| Epps Springs | community in central Swain County on Tuckasegee River. Alt. 1,662. |
| Epsom | community in E Vance County and N Franklin County. Known as Dukes Crossroads in 1881. When a post office was est. there in 1887, the name Duke was rejected because there was another post office by that name. According to tradition, the present name was suggested by Dr. Bennett P. Alston, who noticed a stock of Epsom salts in the local store. |
| Epworth | community in N Edgecombe County served by post office, 1893-1907. |
| Equality | community in SW Mecklenburg County served by post office, 1836-46. Later known as Dixie, which see. |
| Erastus | community in W Jackson County on Little Piney Creek. |
| Erect | community in SE Randolph County. Name suggested to Post Office Department in 1873 by C. M. Tysor, local merchant, to compliment the posture of his neighbor, Tom Bray. |