| Enloe Ridge | NE Swain County in Great Smoky Mountains National Park, a short spur extending E from Hughes Ridge. |
| Ennetts Point | W Carteret County, extending into Bogue Sound W of the mouth of Deer Creek. Named for the Ennett family. |
| Ennice | community in E Alleghany County. Named for Ennice Higgins, daughter of the first postmaster, 1883. |
| Enno | See Holleman's Crossroads. |
| Eno River | rises in N Orange County and flows SE across the county into W Durham County, where it flows E and joins Flat River in forming the Neuse River. Appears on the Moseley map, 1733. The name probably is from the Tuscarora Indian word e-eno (a great way; far off). |
| Eno Township | E central Orange County. |
| Enoch Canal | E Washington County, extends NE from Lake Phelps to Mall Creek. |
| Enoch Mill Creek | rises in S Sampson County and flows SE into Black River. |
| Enochville | town in SW Rowan County. Inc. 1877. Named for St. Enoch's Evangelical Lutheran Church. Long inactive in municipal affairs. Served by post office, 1877-1902. |
| Enola | community in S Burke County. Name is "alone" spelled backwards. |