| Enon | community in E Yadkin County between Logan Creek and Yadkin River. |
| Enon Mountain | in E Transylvania County W of Lydia Creek. |
| Enos Plotts Balsam Mountain | W Haywood County about 5 mi. W of Waynesville. Alt. 6,097. Known by the Cherokee Indians as Sunneehaw. See also Plott Balsam. |
| Ens Creek | See South Fork. |
| Enterprise | community in E Warren County between Stonehouse Creek and Little Stonehouse Creek. |
| Enterprise | former community S of town of Mount Olive in S Wayne County. Now within town limits of Mount Olive. |
| Enterprise | community in N Davidson County. Name chosen to suggest the nature of the inhabitants. |
| Entwistle | community in central Richmond County. |
| Eoka | community in central Columbus County served by post office, 1884-1902. |
| Ephesus | community in S Davie County. Named in 1890 when a post office was est. there in Miles A. Foster's store. |