| Ostin Creek | rises in W central Polk County at the base of Chimney Top and flows NE into Lake Adger on Green River. |
| Ostin Knob | SE Macon County between Brown Gap and East Fork Overflow Creek. |
| Ostwalt | community in S Iredell County. Known as Cambridge for an Associate Reformed Presbyterian Church from the early nineteenth century until 1895, when it took its present name from J. K. Ostwalt's store when it became a post office. |
| Oswego | community in NE Franklin County served by post office, 1892-1903. |
| Otaré | See Mountain Region. |
| Oteen | community in central Buncombe County near the E limits of Asheville. Site of a veterans hospital, est. during World War I for tubercular soldiers. Name said to be an Indian word meaning "chief aim" and descriptive of the hospital's efforts to restore health to the disabled. |
| Othello | community in SE Ashe County. |
| Otis | community in NE Yadkin County served by post office, 1891-1903. |
| Ottanola | community in NE Henderson County. |
| Ottaray | See Mountain Region. |