| Osborne Creek | rises in SE Wilkes County and flows S into Iredell County, where it enters Hunting Creek. |
| Osbornville | community in SE Wilkes County on Osborne Creek. |
| Osburn Ford | shallows in Pigeon River just NE of the town of Clyde in central Haywood County. |
| Osceola | community in central Alamance County served by post office, 1894-1903. |
| Osceola | crossroads community in NE Guilford County. |
| Osceola Lake | central Henderson County, is fed by Findley, Perry, and Tonys Creeks and drained by Shephard Creek. It was formed about 1914 and named for an Indian chief in the area. Covers 12 acres; max. depth 20 ft. |
| Osgood | community in N Lee County. Inc. 1889; charter repealed 1891. Named for local family. Early known as Shakerag, traditionally because two prominent men fought there until their clothes were torn off. Alt. 242. |
| Osmond | community in NE Caswell County. A post office was operated there, 1883-1916. |
| Ossipee | community in W Alamance County on the S side of Altamahaw. Developed after 1890 when a mill was est. there. Inc. 2002. |
| Osteen | community in SW Henderson County on Crab Creek. |