15 July 1850–20 Apr. 1936

Meserve began his professional career in Massachusetts as principal of the high school in Rockland (1877–85) and of Oak Street School in Springfield (1885–89). He then served as superintendent of the Haskell Institute, U.S. Training School for American Indians, in Lawrence, Kans., from 1889 to 1894. In the latter year he became president of Shaw University in Raleigh; his predecessors were Henry Martin Tupper (1831–93), who headed the institution from 1865 to 1893, and Nicholas Franklin Roberts (b. 1849), interim Black president for several months. Meserve remained president until 1919, at which time emphasis was placed on training teachers, clergymen, and physicians; thereafter, he was president emeritus. Meserve Hall on the campus was named for him.
A Baptist, Meserve was licensed to preach but was not ordained. From 1894 to 1897 he served on the board of directors of the North Carolina State School for the Deaf, Dumb, and Blind. A member of the Raleigh Natural History Club for thirteen years, he served as its vice-president and president (1931) and delivered several papers to the membership. In addition, Meserve was a member of Phi Beta Kappa and addressed educational groups. He was president for life of the Meserve Family Association as well as instrumental in founding Capon Springs Conference at Capon Springs, W.Va. He was the author of Abington's Part in the Building of a Great Commonwealth and several pamphlets on Indian affairs. Meserve was a Republican.
On 19 Dec. 1878 he married Abbie Mary Whittier, of Bangor, Maine, who died in Brookline, Mass., on 6 Oct. 1898, leaving one child, Alice Whittier Meserve. On 10 May 1900 he married Julia Frances Philbrick, of Waterville, who died in 1928. In 1907 his daughter Alice served as professor of Latin at Meredith College in Raleigh, and in 1936 she was a member of the faculty of Peace Institute (later College). Meserve was buried in Pine Grove Cemetery, Waterville, Maine.