Ca. 1745–19 Mar. 1823
Hunter acquired large tracts of land in the vicinity of and north of Crabtree Creek, including a mill site from John Giles Thomas which was later sold to Durrell Rogers, Hunter's son-in-law. Another mill site near where Crabtree Creek empties into the Neuse River was sold to Joseph Gales, who converted it into a paper mill.
Hunter's tavern was located on the Cross Creek to Petersburg stage road, and evidently was a well known and popular stopping place. In 1788, when the Hillsborough Convention was held to consider the ratification of the United States Constitution, it was also to fix the unalterable seat of government of the state. After it was determined that the convention would not select a particular point but would leave the choice to the General Assembly, provided that it be within ten miles of the place named, seven locations were nominated, including that of Isaac Hunter in Wake County, proposed by James Iredell. On the second ballot, Hunter's tavern was named as the place within ten miles of which the permanent capital of the state was to be located.
The commission chosen by the General Assembly to select the actual site of the capital met at Hunter's house on 22 Mar. 1792. He apparently hoped to sell a site to the state for the permanent capital, but the commission almost immediately adjourned to the house of Colonel Joel Lane, although its members viewed Hunter's land with other sites the next day. The state, however, bought 1,000 acres from Lane. Hunter eventually sold the tavern property to William Camp, the first husband of his daughter, Elizabeth.
Although Hunter had had extensive landholdings in Wake County, he began to dispose of them, apparently to meet his debts and expenses. In 1800, for example, he traded 627 acres to James House of Franklin County for a stud horse named Rufus. By 1822, his property was reduced; he owned 650 acres and enslaved two people.
Family tradition indicates that Hunter was married twice, but this fact cannot be documented. By his first wife, Rebecca Hart, Hunter had seven children: Jacob, David, Alexander, Michael, Pherebee, Delilah, and Rebecca. By his second, Charlotte Thomas, he fathered Anderson, Norfleet, Elizabeth, Louise, Charlotte, and Frances. He was survived only by his sons Norfleet and Michael and by his daughter, Elizabeth Rogers.
At the time of his death, Hunter had a reputation for intemperance, which apparently contributed to his death. He was heavily in debt when he died, and by 1825 his remaining property was sold to settle his accounts.