1788–14 or 15 June 1838
During the War of 1812, Cameron organized a troop in Fayetteville and held the rank of major. His military duties did not occupy him fully, however, because in 1812 he was the unsuccessful Federalist candidate for Congress against Republican John Culpepper. In 1815 he petitioned the assembly for the office of comptroller of the state, claiming that his capacity to practice law had been lost in the service of his country. He married Eliza Adam in December of 1814, but she did not live long. Cumberland County estate records reveal that Eliza had died and Cameron was administrator of her estate. Eliza and Cameron had one child, Mary. In October of 1818, Cameron married widow Catherine Halliday. The children from this marriage were John Donald, Anna Nash, Catherine LaFayette, Duncan William, and Eliza Adam (named after Cameron's first wife).
Federalists in 1817 obtained for Cameron the job of president of the Fayetteville branch of the U.S. Bank. Republicans in the assembly opposed the bank and placed a tax on it, which Cameron refused to pay when the U.S. Supreme Court denied the right of states to tax instrumentalities of the national government (McCulloch v. Maryland, 1819). In 1820, Cameron was again in the House of Commons from Fayetteville and active in the movement to revise the state constitution. Cameron also served as the Grand Master for the North Carolina Masonic Lodge in 1820 and again in 1821. Evidence that Cameron suffered financially first appears in 1823 when 550 acres of land was listed as part of a Fayetteville County Sherriff's sale to cover unpaid taxes from 1821. In 1823, he was a delegate to the Internal Improvements Convention in Raleigh; by this time he was beginning to move away from his old Federalist ties.
In 1825 it was announced that Cameron would become the editor of the Fayetteville North Carolina Journal, which under his leadership became an abrasive champion of the cause of Andrew Jackson. Around the same time, Cameron was apparently again in financial straits as he listed land and household items for sale in the Fayetteville Observer on October 20th. This newspaper article listed for sale seventy "valuable slaves ... consisting of men, women, boys, and girls." In 1827 the editor was candidate, against his old opponent Culpepper, for the Fayetteville seat in Congress. Their political roles were reversed, but Culpepper was again successful. In 1829, Culpepper having retired, Cameron campaigned again as the Jackson candidate, this time against National Republican Edmund Deberry. Deberry, who accused Cameron of being overbearing and of having squandered two fortunes, won by slightly more than two hundred votes.
Defeated politically and in need financially, Cameron had to sell the Journal in 1830. Shortly thereafter, President Jackson gave him an appointment as consul to Vera Cruz, but the revolutionary state of Mexico and the low pay of State Department employees at that period soon reduced Cameron's financial circumstances even further. He again contacted his influential friends in Congress to find him a better job. This time he received an appointment as judge of the Western District Court of Florida, and in 1832 he moved to Pensacola. Six years later he boarded the new steamship Pulaski at Savannah for a trip north. Near midnight on 14 June 1838, the starboard boiler of the ship exploded. There were almost one hundred victims, and Cameron's body was never found.