| Little Creek | rises in N Lincoln County and flows NE into Catawba River. |
| Little Creek | rises in SE Macon County and flows SE into Big Creek. |
| Little Creek | rises in NE Madison County and flows S into Big Laurel Creek. |
| Little Creek | rises in SW Madison County and flows NE into Spring Creek. |
| Little Creek | rises in W Madison County and flows E into Meadow Fork. |
| Little Creek | rises in E central Moore County and flows NW into McLendons Creek. |
| Little Creek | rises in SE Moore County and flows S into Little River. |
| Little Creek | rises in SW Nash County and flows SW into Moccasin Creek. |
| Little Creek | is formed in SE Orange County by the junction of Booker Creek and Bolin Creek; it flows E into SW Durham County, where it flows SE into New Hope Creek. |
| Little Creek | rises in W Stanly County and flows SW into Big Bear Creek. |