| Squirrel Gap | N Transylvania County between Laurel Brook and South Fork Mills River. |
| Squirrels Gap | W Madison County on the SW end of Hot Springs Mountain. |
| Squyars Canal | See New Lake Fork. |
| St. Andrew's Parish | Church of England, Tyrrell County, est. 1729 with the formation of the county and coextensive with it. Previous to the formation of the county, the territory had been South Shore Parish (est. 1722), Chowan County. In 1767 St. Andrew's Parish had 594 white taxables. See also St. Paul's Parish. |
| St. Asaph's District | one of the districts into which Orange County was divided at the time of the 1790 census. It contained 199 heads of families. |
| St. Barnabas’ Parish | Church of England, Hertford County, est. 1759 with the formation of the county and coextensive with it. The parish in 1767 had 900 white taxables. |
| St. Bartholomew's Parish | Church of England, Chatham County, est. with the formation of the county in 1770 and coextensive with it. St. Bartholomew's Parish of the Episcopal Church still functions in Pittsboro. |
| St. Clair Creek | rises in Jackson Swamp, E Beaufort County, and flows SE into Pamlico River. |
| St. Colomb Parish | See Donegal County. |
| St. David's District | one of the districts into which Caswell County was divided at the time of the 1790 census. It contained 166 heads of families. |