| Buffalo Creek | rises in N Franklin County and flows SE into Sandy Creek. |
| Buffalo Creek | rises in NW Franklin County and flows NE into Tar River. |
| Buffalo Creek | is formed by the junction of North Buffalo Creek and South Buffalo Creek in NE Guilford County. It flows NE into Reedy Fork Creek. Named after 1755 but before 1758. |
| Buffalo Creek | rises in SW Harnett County and flows S into E Moore County (formerly Hoke County), where it enters Little River. |
| Buffalo Creek | rises in W Hoke County and flows SW into Lumber River. |
| Buffalo Creek | rises in W Moore County and flows NE into Deep River. |
| Buffalo Creek | rises in NE Orange County and flows SE into Durham County, where it enters North Fork Little River. |
| Buffalo Creek | rises in N Richmond County and flows SW into Little River. |
| Buffalo Creek | rises in NW Rutherford County and flows S into Broad River. |
| Buffalo Creek | rises in E Stokes County and flows into Rockingham County and into Mayo River. |