| Squyars Canal | See New Lake Fork. |
| St. Andrew's Parish | Church of England, Tyrrell County, est. 1729 with the formation of the county and coextensive with it. Previous to the formation of the county, the territory had been South Shore Parish (est. 1722), Chowan County. In 1767 St. Andrew's Parish had 594 white taxables. See also St. Paul's Parish. |
| St. Asaph's District | one of the districts into which Orange County was divided at the time of the 1790 census. It contained 199 heads of families. |
| St. Barnabas’ Parish | Church of England, Hertford County, est. 1759 with the formation of the county and coextensive with it. The parish in 1767 had 900 white taxables. |
| St. Bartholomew's Parish | Church of England, Chatham County, est. with the formation of the county in 1770 and coextensive with it. St. Bartholomew's Parish of the Episcopal Church still functions in Pittsboro. |
| St. Clair Creek | rises in Jackson Swamp, E Beaufort County, and flows SE into Pamlico River. |
| St. Colomb Parish | See Donegal County. |
| St. David's District | one of the districts into which Caswell County was divided at the time of the 1790 census. It contained 166 heads of families. |
| St. David's Parish | Church of England, Cumberland County, est. 1754 with the formation of the county and coextensive with it. In 1767 the parish had 899 white taxables, described as "mostly Scotch—Support a Presbyterian Minister." |
| St. Gabriel's Parish | Church of England, Duplin County, est. 1750 with the formation of the county and coextensive with it. In 1767 there were 1,071 white taxables in the parish. St. Gabriel's Parish of the Episcopal Church functions in Faison at present, though there is some question of its unbroken descent from the colonial parish. |