| Spruce Pine | town in S Mitchell County on North Toe River. Alt. 2,620. Inc. 1907. Named for a large Carolina hemlock, locally called spruce pine, which grew near a tavern operated by Isaac English. Produces apparel, hosiery, textiles, minerals, and lumber. |
| Spruce Pine Cove | N Buncombe County between Wiley Mountain and Coles Cove. |
| Spruce Pine Mountain | SW Avery County. |
| Spruce Pine Ridge | NE Buncombe County between Waterfall and Carter Creeks. |
| Spruce Pinnacle | NE Buncombe County on Big Fork Ridge. |
| Spruce Ridge | S Haywood County between Cherry Cove Creek and Shiny Creek. |
| Spruills Bridge | E Washington County SE of Creswell. First known as Samuel Spruills Landing; designated by the General Assembly in 1740 as a point for a warehouse for receipt and shipping of crown quitrents. Called Spruills Landing as late as 1812. |
| Spur Ridge | E Mitchell County parallel to Green Cove Creek. |
| Spurgeon | community in S Wilkes County near Hunting Creek. |
| Spurgeon Creek | rises in NE Davidson County and flows S into Abbotts Creek. |