| South Rodanthe | See Waves. |
| South Salisbury | unincorporated outskirts of city of Salisbury, E central Rowan County. |
| South Second Creek | rises in S Rowan County and flows NE into High Rock Lake. Appears as Lower Second Creek on the Collet map, 1770; as Dutch Second Creek on the Price map, 1808, and the MacRae map, 1833; as Second Creek on the Kerr map, 1882; and as South Second Creek on recent maps. |
| South Shoal Creek | See Shoal Creek. |
| South Shore Parish | See St. Andrew's Parish; St. Paul's Parish. |
| South Skitty Branch | rises in E Macon County and flows SW into Cliffside Lake. |
| South Spring Top | on the Haywood-Transylvania county line. |
| South Stony Fork Creek | rises in E Watauga County and flows SE into Wilkes County and into Stony Fork Creek. |
| South Sunbury | community in central Gates County on Raynor Swamp. |
| South Toe River | is formed in S Yancey County by the junction of Left Prong South Toe River and Right Prong South Toe River. It flows N to join North Toe River on the Mitchell-Yancey county line to form Toe River. |