| Scarlet Ridge Creek | rises in N Swain County in Great Smoky Mountains National Park and flows SE into Jonas Creek. |
| Schenck Forest | See Carl Alwin Schenck Forest. |
| Schencks Station | community in S Cleveland County. |
| Schene Wolf Creek | rises near Organ and Lower Stone Churches approx. 5 mi. SW of Rockwell, SE Rowan County, and flows S into NE Cabarrus County, where it enters Dutch Buffalo Creek. Probably named by early German settlers, Schene being derived from schön (beautiful). Sometimes also called Jennie Wolf Creek. |
| Schley | community in E Orange County served by post office, 1898-1907. |
| Schlosstown | community in N Franklin County. Known locally as "Slosh." |
| Scholl | community in W Scotland County. |
| School House Branch | rises in W Carteret County and flows SW into Hadnot Creek. |
| School House Branch | rises in W Watauga County and flows SW into Watauga River. |
| Schoolhouse Branch | rises in central Cherokee County and flows SE into Marble Creek. |