| Salvage Island | See Core Banks. |
| Salvo | community on Hatteras Island, E Dare County. Formerly known as Clarks or Clarksville. |
| Salyer's Bay | See Sulliers Bay. |
| Sam Branch | rises in central Cherokee County and flows NW into Valley River. |
| Sam Branch | rises in S Haywood County and flows NW into West Fork Pigeon River. |
| Sam Branch | rises in S Haywood County and flows SE into Nick Creek. |
| Sam Cove | NW Graham County on Deep Creek. |
| Sam Doane Mountain | on Madison-Yancey County line between Moore Gap and Paint Gap. Named for an early settler. |
| Sam Gap | SE Buncombe County between Flint Knob and Round Mountain. |
| Sam Knob | S Haywood County between Sam Branch and Flat Laurel Creek. Alt. 6,030. |