| Sally's Creek | rises in W Caldwell County and flows SE into Johns River. |
| Salmon Creek | rises in E Bertie County and flows SE into Chowan River. Appears as Flatt's Creek on the Comberford map, 1657, but as Salmon Creek on the Ogilby map, 1671. Probably named for an early settler. Area known as "Seedbed of the Colony" due to residence of early settlers, such as Nathaniel Batts, and leaders, such as Charles Eden, royal governor. |
| Salmon Creek | See Southwest Creek. |
| Salola | See Sugarloaf Mountain. |
| Salola Branch | rises in N Swain County S of Clingmans Dome and flows SE into Noland Creek. Salola was the Cherokee Indian word for squirrel. |
| Sals Creek | rises in S Transylvania County and flows NE into Glady Fork. |
| Salser Branch | rises in central Macon County and flows E into McDowell Branch. |
| Salt Branch | rises in S Onslow County and flows E into Chadwick Bay. |
| Salt Rock Gap | S Yancey County on Buncombe Horse Range Ridge. |
| Salter Creek | rises in NE Carteret County and flows SE into Nelson Bay. |