| Big Creek | rises in SE Macon County and flows SW into Rabun County, Ga., where it enters Overflow Creek. |
| Big Creek | rises in E Macon County and flows SW into Lake Sequoyah. |
| Big Creek | rises in NW Henderson County and flows ne, where it joins Fletcher Creek in forming North Fork. |
| Big Creek | rises in W Haywood County near lat. 35°42'05" N., long. 83°14'50" W., and flows NE into Pigeon River. |
| Big Creek | rises in S Haywood County and flows E into West Fork Pigeon River. |
| Big Creek | rises in N Carteret County and flows NE into South River. |
| Big Creek | rises in E Cumberland County and flows NE and SE into South River on the Cumberland-Sampson county line. |
| Big Creek Township | NW Stokes County. |
| Big Cypress Swamp | rises in S Columbus County and flows S to join Monie Swamp in forming Seven Creeks. |
| Big Dam Branch | rises in N Cherokee County in the Snowbird Mountains and flows SW into Hyatt Creek. |