| Big Cove | SW Buncombe County near the headwaters of Webb Branch. |
| Big Cove Branch | rises in NE Cherokee County and flows SW into Dan Holland Creek. |
| Big Crabtree Creek | rises in SE Yancey County and flows N on the Mitchell-Yancey county line into North Toe River. |
| Big Craggy | mountain on the McDowell-Yancey county line near the head of Big Lost Cove Creek. |
| Big Craggy | See Craggy Dome. |
| Big Creek | rises in N Yancey County and flows NE and SE into Cane River. |
| Big Creek | rises in SW Swain County and flows N into Silvermine Creek. |
| Big Creek | rises in NE Surry County and flows SE into Stokes County, where it enters Dan River. |
| Big Creek | rises in E Montgomery County and flows NW into Little River. |
| Big Creek | rises in N Madison County and flows S into Shelton Laurel Creek. |