| Spurgeon | community in S Wilkes County near Hunting Creek. |
| Spurgeon Creek | rises in NE Davidson County and flows S into Abbotts Creek. |
| Spurrier | community in W Mecklenburg County. |
| Squally Creek | rises in W Graham County and flows E into West Buffalo Creek. |
| Squhawky | See Williamston. |
| Squirrel Branch | rises in SW Gaston County and flows NE into Crowders Creek. |
| Squirrel Branch | rises in N Guilford County and flows E into Reedy Fork Creek. |
| Squirrel Branch | rises in W Madison County near Squirrels Gap and flows W into Spring Creek. |
| Squirrel Creek | rises in central Avery County and flows W into North Toe River. |
| Squirrel Creek | rises in W Lenoir County and flows N into Neuse River. |