| South Henderson | unincorporated outskirts of city of Henderson in S central Vance County. |
| South Hominy | community in SW Buncombe County near the junction of Glady Fork and South Hominy Creek. |
| South Hominy Creek | rises in SW Buncombe County near Brooks Gap and flows NE into Hominy Creek. |
| South Hyco Creek | rises in N Orange and SE Caswell Counties and flows NE into Person County, where it joins North Hyco Creek in forming Hyco River. The part of South Hyco Creek that lies in Caswell County is sometimes called Sugartree Creek. |
| South Lake | NW mainland of Dare County. It drains into Alligator River. |
| South Lake | artificial pond on Long Creek in S Vance County. Covers 14 acres, with max. depth of 15 ft. Originally named Beckham Millpond and was formed sometime in the nineteenth century. Name was changed in early 1940s, when the lake was bought by a social club. The mill is still standing; lake is used for recreation (fishing, swimming, boating). The name appeared on the soil survey map of 1913 as Beckon Mill. |
| South Leopard Creek | an inlet of North River into the mainland S of North Leopard Creek in E Carteret County. |
| South Lowell | community in NW Durham County between Buffalo and Horse Creeks on the N side of North Fork Little River. |
| South Mills | town in NW Camden County; inc. 1883, but not active in municipal affairs. Prior to 1800 the community was known as New Lebanon because the junipers that formerly grew in the area adjacent to the Dismal Swamp suggested the biblical reference to the tall cedars of Lebanon. Post office was New Lebanon from 1797 until 1839, when the name was changed to South Mills because waters from a spillway at the S end of the Dismal Swamp Canal were used to turn wheels of mills there. |
| South Mills Township | N Camden County. |