| Great Branch | rises in NE Pitt County and flows SE into Meadow Branch. |
| Great Coharie Creek | rises in N Sampson County and flows S to join Little Coharie Creek in forming Coharie River. Appears as Cohary Swamp on the Collet map, 1770. |
| Great Coneghta Pocosin | See Conetoe Creek. |
| Great Contentnea Creek | See Contentnea Creek. |
| Great Coteckney Creek | See Contentnea Creek. |
| Great Craggy Mountains | range in NE Buncombe County extending S from Balsam Gap to the Swannanoa River. Alt. 3,332. Known by the Cherokee Indians as Sunnatee (morning). |
| Great Creek | rises in North River Pocosin in S Camden County and flows E into North River. |
| Great Creek | tidal creek in Jarrett Bay, SE Carteret County. |
| Great Creek | See Deep Creek; Smith Creek. |
| Great Dismal Swamp | See Dismal Swamp. |