| Big Rocky Creek | See Patterson Creek. |
| Big Rough Knob | E central Avery County. |
| Big Sandy Creek | rises in NE Wilkes County and flows SW into East Prong Roaring River. |
| Big Savanna | N Tyrrell County, is a slough extending NE in an arc N of Mills Ridge from near the community of Levels to Alligator Creek. |
| Big Savannah | central and NW Pender County. Originally covered over 2,000 acres, lying between 50 and 60 ft. above sea level. A flat, treeless area, surrounded by pine woods. Water table generally at or close to the surface. Much of the Big Savannah has been drained and cultivated. Once noted for the large variety of wildflowers that grew among the grasses. Also known as Burgaw Savannah. |
| Big Scaly | peak in SE Clay County at the NE end of Scaly Ridge. Alt. 5,070. |
| Big Shoal Branch | rises in SW Macon County and flows E into Big Indian Creek. |
| Big Shoeheel Creek | rises in N Scotland County and flows S through W Robeson County into South Carolina, where it enters Little Pee Dee River. See also Maxton. |
| Big Snowball Mountain | See Snowball Mountain. |
| Big Spring | community in N Jackson County served by post office, 1852-1903. |