| Big Branch | rises in SE Alexander County and flows SE into Elk Shoal Creek. |
| Big Branch | rises in W Avery County and flows NE into Horse Creek. |
| Big Branch | rises in W Avery County and flows SW into Roaring Creek. |
| Big Buckeye Cove | SE Haywood County on the head of East Fork Pigeon River. |
| Big Buffalo Creek | rises in central Lee County and flows NW into Deep River. |
| Big Bugaboo Creek | rises in NE Wilkes County and flows S into Yadkin River. |
| Big Butt | on the Madison County, N.C.-Greene County, Tenn., line. Alt. 4,836. |
| Big Butt | S Macon County between Mooney Gap and Bearpen Gap. |
| Big Butt Creek | rises in NE Buncombe County and flows NW into Straight Creek. |
| Big Butt Knob | on the Buncombe-Yancey county line between Flat Spring Knob and Little Butt Knob. |