| Spikes Creek | rises in SW Gates County and flows SE into Chowan River. |
| Spillcorn Creek | rises in N Madison County and flows SW into Big Laurel Creek. Said to have been named because an early settler spilled a load of corn in the creek. |
| Spilona | community in central Johnston County served by post office, 1882-1903. |
| Spindale | town in central Rutherford County. Est. 1916 by K. S. Tanner and named by him for its location in a valley where cotton mills were est. Inc. 1923. Isothermal Community College, est. 1966, is located there. |
| Spit Bay | between Davis Island and Davis Shore in Core Sound in E Carteret County. |
| Spivey Creek | rises in NW Yancey County and flows NW into Tennessee, where it enters Indian Creek. |
| Spivey Gap | central Buncombe County between Spivey and Miller Mountains. |
| Spivey Mountain | central Buncombe County N of Deaver View Mountain. Alt. 3,317. |
| Spiveys Corner | community in N Sampson County near Little Coharie Creek. Formerly known also as West Crossroads. |
| Spiveys Pond | See Lake Tabor. |