| Buffalo Creek | rises in SW Harnett County and flows S into E Moore County (formerly Hoke County), where it enters Little River. |
| Buffalo Creek | rises in W Hoke County and flows SW into Lumber River. |
| Buffalo Creek | rises in W Moore County and flows NE into Deep River. |
| Buffalo Creek | rises in NE Orange County and flows SE into Durham County, where it enters North Fork Little River. |
| Buffalo Creek | rises in N Richmond County and flows SW into Little River. |
| Buffalo Creek | rises in NW Rutherford County and flows S into Broad River. |
| Buffalo Creek | rises in E Stokes County and flows into Rockingham County and into Mayo River. |
| Buffalo Creek | rises in NE Stokes County and flows NE into Rockingham County, where it enters Mayo River. |
| Buffalo Creek | rises in S Union County and flows SW into South Carolina, where it enters Lynches Creek. |
| Buffalo Creek | rises in S Vance County and flows S into Tar River. Water-ground corn meal is produced commercially on the creek. |