| Isaac Parlier's Creek | See Purlear Creek. |
| Isaac Walton Lake | formerly Water Works Lake, in W Person County on Storys Creek at the mouth of Satterfield Creek. Formed prior to 1928. Covers 213 acres; max. depth 25 ft. Owned by the town of Roxboro. |
| Isenhour | community in NE Stanly County. Grew up around Isenhour Brick Yard in early twentieth century. |
| Isenhour Mine | former gold mine in NE Cabarrus County on Little Buffalo Creek. |
| Isinglass Creek | rises in N Franklin County and flows NE into Little Shocco Creek. |
| Isinglass Ridge | S Graham County, extends SE from Sassafras Ridge to Little Snowbird Creek. Named for isinglass or mica mined in the area. |
| Island Borough | former town in E Rowan County. Inc. and authorized to be laid out in 1795 on the Yadkin River opposite the E end of Big Island, which see. Site is about 3 mi. NE of Spencer. Intended to promote navigation on the river, the town was to be built on land owned by Edward Yarborough. Little if any development took place at the site. |
| Island Branch Swamp | connects Resolution Branch to Musselshell Creek in NW Jones County. |
| Island Creek | rises in SE Alexander County and flows S into Catawba River. |
| Island Creek | rises in E Anson County and flows SE into Pee Dee River. |