| Deserta Arenosa | See Sandhills. |
| Deserta Montana | See Sandhills. |
| Deserter Island | a land formation in S Duplin County surrounded by swamp. |
| Desolation Branch | rises in NW Swain County in Great Smoky Mountains National Park and flows SW into Roaring Creek. It was named after some early hunters were thoroughly soaked in a cold rain there. |
| Dester | community in S Union County. |
| Deuces Quarter | See Jews Quarter Island. |
| Devenport | See River Neck. |
| Devereux's Ferry | See Bridgers Creek. |
| Devil Den Ridge | N Macon County between Matlock Creek and Wests Branch. |
| Devil Knob | E Madison County on Laurel Creek. |