| Spice Bottom Creek | rises in SW Watauga County and flows NE into Watauga River. |
| Spice Cove | the valley through which Spice Cove Branch flows in N Buncombe County. |
| Spice Cove Branch | rises near Louis Ray Knob in NE Buncombe County and flows NW through Spice Cove into North Fork Ivy Creek. |
| Spice Cove Branch | rises in W Transylvania County and flows SE into North Fork French Broad River. |
| Spice Creek | rises in W Watauga County and flows NE into Laurel Creek. |
| Spicers Bay | S Onslow County in Stump Sound. Named for John Spicer. |
| Spices Cove | NE Buncombe County between Pinnacle Mountain and Dillingham Creek. |
| Spies (speece) | community in NW Moore County. |
| Spikes Creek | rises in SW Gates County and flows SE into Chowan River. |
| Spillcorn Creek | rises in N Madison County and flows SW into Big Laurel Creek. Said to have been named because an early settler spilled a load of corn in the creek. |