| Second Creek | community on the creek of the same name in N central Tyrrell County. |
| Second Creek | See North Second Creek; South Second Creek; Back Creek. |
| Second Creek Bluff | at the mouth of Second Creek in E Tyrrell County. |
| Second Creek Point | E Tyrrell County, extends from the mainland into Alligator River near the mouth of Second Creek. |
| Second Falls | the middle of a series of three waterfalls on Yellowstone Prong, S Haywood County. |
| Second Hurricane Branch | rises in E Swain County and flows SW into Yalaka Creek. |
| Second Potts Creek | rises in W Davidson County and flows S into High Rock Lake on Yadkin River. Appears on the Collet map, 1770, as Potts Creek. |
| Secotan | an Indian village once located on the S side of Pamlico River in what is now E Beaufort County in the vicinity of Hobucken; visited by John White and other explorers based on Roanoke Island in the sixteenth century. The name meant "town at the bend of a river." Appears as Secoton on the White map, 1585; as Secota on the De Bry map, 1590; and as Secotan on the Velasco map, 1611. See also Seco. |
| Sedalia | community in E Guilford County. The Alice Freeman Palmer Memorial Institute, a junior college and high school for African American women est. 1901, operated there until 1960s. Campus now a State Historic Site. |
| Sedgefield | community in W central Guilford County. Named for the fields of sedge (grasslike plants) in the vicinity. English-style inn opened 1927. Golf course hosts national tournaments. |