| Saconon | community in E Henderson County on Little Hungry Creek served by post office, 1913-23. |
| Saddle Gap | N Transylvania County between Looking Glass Creek and Avery Creek. |
| Saddle Mountain | on the Alleghany-Surry county line. |
| Saddle Mountain Creek | rises in W Surry County and flows SE into Mitchell River. |
| Saddle Tree Gap | W Graham County between the headwaters of Hangover Creek and Deep Creek. |
| Saddleback | ridge in NW Swain County in Great Smoky Mountains National Park between Roaring Creek and Desolation Branch. Its center is near lat. 35°33'26" N., long. 83°40'48" W. |
| Saddletree Swamp | rises in N Robeson County and flows S into Lumber River. |
| Saddletree Township | central Robeson County. |
| Sadler | community in E Rockingham County served by post office, 1898-1910. |
| Safe | community in SW Duplin County served by post office, 1888-1903. Name derived from the fact that the first postmaster, Jacob Carr, operated a store and therein had a large safe, the only one in the area. |