| Panther Creek | rises in E Duplin County and flows W into Northeast Cape Fear River. |
| Panther Creek | rises in E Durham County and flows NE into Neuse River. |
| Panther Creek | rises in W Forsyth County and flows SE into Yadkin River. |
| Panther Creek | rises in E Graham County and flows NE into Little Tennessee River. |
| Panther Creek | rises in central Haywood County and flows W into Pigeon River. |
| Panther Creek | rises in W Lenoir County and flows N into Dailys Creek. |
| Panther Creek | rises in E Pitt County and flows SE into Tar River. |
| Panther Creek | rises in E Rowan County and flows NE about 6 mi. into High Rock Lake. |
| Panther Creek | rises in NE Sampson County and flows NE into Duplin County, where it enters Goshen Swamp. |
| Panther Creek | rises in W Wake County and flows SW into Chatham County, where it turns NW to flow into Northeast Creek. |