fl. 1670–75
See also: Lederer Expedition

On 19 Mar. 1670 Lederer reached the Blue Ridge northwest of present Charlottesville but found neither a pass nor the "South Sea." On his second "march," leaving Stegge's plantation (present-day Richmond) on 20 May 1670 with a Susquehanna Indian as guide, he reached Akenatzy (Occaneechi Islands near present-day Cartersville on the Staunton River) and continued southwest across the Yadkin ford near Spencer, N.C., through the Uwharrie Mountains to the Catawba River, probably near Rock Hill, S.C. Fearful of enslavement by Spaniards, he then returned by a more easterly route, reaching Appomattox (Abraham Wood's trading post) on 20 July 1670. This important, influential journey helped open the great Indian Trading Path (now roughly followed by Interstate 85) to the lucrative Virginia fur trade that flourished with the Catawba and Cherokee for several decades.
Lederer was a perceptive observer of the Indian settlements that he encountered; his comments on the location, customs, and beliefs of the Indian tribes are generally astute and ethnologically valuable. Unfortunately, his later published account with its accompanying map gives three geographic misconceptions: he describes the Piedmont as a savanna under water several months of the year, places a nonexistent lake in western Carolina, and says he crossed "a barren Sandy desert" on his return journey. The reasons for these errors are explicable: he followed the marshy river valleys leading up to the Virginia Blue Ridge during the spring freshets; the location and description of his "Lake Ushery," which he places beyond his actual route of travel, are similar to those found on most maps since Mercator's in 1606; and the "Arenosa Desert" resulted from his memory of crossing the Carolina pine barrens in July heat. These errors, soon incorporated in the first Lords Proprietors' map of Carolina (1672) by John Ogilby, the royal geographer, and followed by many later maps of the Southeast, have caused some historians to question unjustly Lederer's entire account and dismiss it as unimportant.

By 1674 or before, Lederer had moved again, this time to Connecticut where he was entertained by Governor John Winthrop, who sent him on medical missions and later corresponded with him. Lederer quickly developed a flourishing medical practice in Stratford and Stamford, but in early 1675 he decided to return via Barbados to Germany and disappeared from the American scene.