"Inventive Spirit: Pain Relief"
by Suzanne Mewborn
Reprinted with permission from the Tar Heel Junior Historian. Fall 2006.
Tar Heel Junior Historian Association, NC Museum of History 
When was aspirin invented? The father of modern medicine, Hippocrates , working between 460 and 377 BC, left records of pain-relief treatments that included the use of powder made from the bark and leaves of the willow tree to help heal headaches, body pains, and fevers. In 1829 scientists discovered a pain-relieving compound called salicin  in willow plants. Salicylic acid was tough on stomachs. In 1853 Charles Gerhardt  neutralized the acid but did not pursue marketing his new find. Several years later, Feliz Hoffman , an employee of German company Bayer, found Gerhardt’s formula, marketed it, and sold it. Aspirin was patented March 6, 1889, and sold as a powder. Tablets came along in 1915.
Why headache powders? It was very common for druggists in the early 1900s to buy raw materials and make their own prescriptions. Pills were harder for the local druggist to make, so pain-relief powders developed as a regional heritage.
Stanback Headache Powder : Thomas Stanback, of Salisbury , created his headache powder in 1911, as a young pharmacist in a Thomasville  drugstore. He moved to Spencer  to work at the Rowan Drug Store while its pharmacist vacationed. There he gave samples of his new headache power containing aspirin to railroaders, who carried it up and down the Southern line. Stanback persuaded his younger brother Fred to try selling the powders to area stores. Thomas prepared the product by night, and Fred sold it by day. Thomas used a flour sifter, then a sifter with a hand crank to speed production. The brothers began renting a building in Spencer in 1927 and sold their powders from Richmond, Virginia , to Columbus, Georgia . In 1932 a new Italian-made folding machine was purchased, and production moved to Salisbury. Full-scale national advertising began.
Goody’s Headache Powder : Winston-Salem  pharmacist Martin “Goody” Goodman created his headache powder in 1932. A. Thad Lewallen Sr. bought the formula and trademark a few years later. His marketing strategy based on sampling introduced Goody’s Headache Powder to the Southeast and beyond. Samples were handed out to factory workers at shift changes. This promotional method created a dedicated following. Demand soon outstripped production. In 1941 a modern production facility and an increased sales force furthered boosted Goody’s.
Bromo-Seltzer: Isaac Edward Emerson , a native of Chapel Hill and 1879 graduate of the University of North Carolina at Chapel Hill , moved to Maryland in 1881. In 1888, working behind the prescription counter of a modest drugstore, he created a remedy for headaches and indigestion. His background in chemistry and pharmacy led to the granular effervescent salt he named Bromo-Seltzer and packaged in cobalt blue glass bottles.
At the time of this article’s publication, Suzanne Mewborn served as the program coordinator for the Tar Heel Junior Historian Association at the North Carolina Museum of History.
NC Digital Collections resources on the history of medicine  (Government & Heritage Library and NC State Archives)
NC LIVE resources on headache powder .
Resources in libraries about the history of medicine  [via WorldCat]
1 January 2006 | Mewborn, Suzanne